123
9. Creutzfeldt HG. “Uber eine eigenartige herdformige Erkrankung des Zentral-nervensystems.” Z Ges Neurol
Psychiatr. 1920 57(issue):1-18.
10. Bockman JM et al. “Creutzfeldt-Jakob disease prion proteins in human brains.” N Engl J Med. 1985 312(2):73-8.
11. Klatzo I et al. “Pathology of kuru.” Lab Invest 1959 8:799-847.
12. Hadlow WJ. “Scrapie and kuru.” Lancet. 1959 2:289-90.
13. Prusiner SB. “Prions and neurological diseases.” N Engl J Med. 1987 317(25):1371-81.
14. Donnelly CA. “Bovine spongiform encephalopathy in the United States—an epidemiologist’s view.” N Engl J
Med 2004 350(6):539-42.
15. Prions on the trail of killer proteins. University of Utah website. http://learn.genetics.utah.edu/content/
begin/dna/prions. Accessed 17 January 2011.
16. Zobeley E et al. “Infectivity of scrapie prions bound to a stainless steel surface.” Molecular Medicine.
1999 5(issue):240-3.
17. Brown P. “Environmental causes of human spongiform encephalopathy.” In: Baker H, Ridly RM, eds. Prion
Diseases., Totowa NJ, Human Press 1996:105-118.
18. Questions and Answers: Creutzfeldt-Jakob Disease Infection-Control Practices. .CDC website. http://www.
cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm. Accessed 17 January 2011.
19. “Iatrogenic vCJD from surgical instruments” (editorial). BMJ. 2001 322 (issue):1558-9.
20. Op cit 5.
21. Lemmer K et al. “Decontamination of surgical instruments from prion proteins: in vitro studies on the detach-
ment, destabilization and degradation of PRPSc bound to steel surfaces.” J Gen Virol. 2004 85(issue):3806-16.
22. Op cit 5.
23. WHO Infection Control Guidelines for Transmissible Spongiform Encephalopathies. WHO website. http://
www.who.int/csr/resources/publications/bse/whocdscsraph2003.pdf. Accessed 17 January 2011.
24. Prion Disease in Mice May Help Advance Alzheimer’s. Meridian Health Wellness Center website. http://
wellnesscenter.meridianhealth.com/RelatedItems/6,636679. Accessed 17 January 2011.
Published in Regulatory Focus, February 2011. Copyright © 2011 Regulatory Affairs Professionals Society.
Prions—Still a Mystery!
9. Creutzfeldt HG. “Uber eine eigenartige herdformige Erkrankung des Zentral-nervensystems.” Z Ges Neurol
Psychiatr. 1920 57(issue):1-18.
10. Bockman JM et al. “Creutzfeldt-Jakob disease prion proteins in human brains.” N Engl J Med. 1985 312(2):73-8.
11. Klatzo I et al. “Pathology of kuru.” Lab Invest 1959 8:799-847.
12. Hadlow WJ. “Scrapie and kuru.” Lancet. 1959 2:289-90.
13. Prusiner SB. “Prions and neurological diseases.” N Engl J Med. 1987 317(25):1371-81.
14. Donnelly CA. “Bovine spongiform encephalopathy in the United States—an epidemiologist’s view.” N Engl J
Med 2004 350(6):539-42.
15. Prions on the trail of killer proteins. University of Utah website. http://learn.genetics.utah.edu/content/
begin/dna/prions. Accessed 17 January 2011.
16. Zobeley E et al. “Infectivity of scrapie prions bound to a stainless steel surface.” Molecular Medicine.
1999 5(issue):240-3.
17. Brown P. “Environmental causes of human spongiform encephalopathy.” In: Baker H, Ridly RM, eds. Prion
Diseases., Totowa NJ, Human Press 1996:105-118.
18. Questions and Answers: Creutzfeldt-Jakob Disease Infection-Control Practices. .CDC website. http://www.
cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm. Accessed 17 January 2011.
19. “Iatrogenic vCJD from surgical instruments” (editorial). BMJ. 2001 322 (issue):1558-9.
20. Op cit 5.
21. Lemmer K et al. “Decontamination of surgical instruments from prion proteins: in vitro studies on the detach-
ment, destabilization and degradation of PRPSc bound to steel surfaces.” J Gen Virol. 2004 85(issue):3806-16.
22. Op cit 5.
23. WHO Infection Control Guidelines for Transmissible Spongiform Encephalopathies. WHO website. http://
www.who.int/csr/resources/publications/bse/whocdscsraph2003.pdf. Accessed 17 January 2011.
24. Prion Disease in Mice May Help Advance Alzheimer’s. Meridian Health Wellness Center website. http://
wellnesscenter.meridianhealth.com/RelatedItems/6,636679. Accessed 17 January 2011.
Published in Regulatory Focus, February 2011. Copyright © 2011 Regulatory Affairs Professionals Society.
Prions—Still a Mystery!